Population-based meta-analysis of roxithromycin pharmacokinetics: dosing implications of saturable absorption and protein binding | Zendy

Michael Dolton | Zendy; David Z. D’Argenio | Zendy

Open Access

Population-based meta-analysis of roxithromycin pharmacokinetics: dosing implications of saturable absorption and protein binding

Author(s) -

Michael Dolton,

David Z. D’Argenio

Publication year - 2016

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkw553

Subject(s) - pharmacokinetics , roxithromycin , dosing , medicine , population , pharmacology , regimen , pharmacodynamics , physiologically based pharmacokinetic modelling , nonmem , antibiotics , chemistry , erythromycin , biochemistry , environmental health

The macrolide antibiotic roxithromycin has seen widespread clinical use for several decades; however, no population pharmacokinetic analysis has been published. Early studies indicated saturation of protein binding and absorption at doses within the approved range, which may impact pharmacodynamic target attainment since regimens of 150 mg twice daily and 300 mg once daily are used interchangeably in clinical practice. This study aimed to develop a population-based meta-analysis of roxithromycin pharmacokinetics, and utilize this model to inform optimal dosing regimens.

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