Therapeutic drug monitoring and use of an adjusted body weight strategy for high-dose voriconazole therapy | Zendy

Patrick Richards | Zendy; Kimberlyn M. Dang | Zendy; Carol A. Kauffman | Zendy; Kay Lyn Stalker | Zendy; David Sudekum | Zendy; Lisa Kerr | Zendy; Michelle Brinker-Bodley | Zendy; Beena Cheriyan | Zendy; Nina West | Zendy; Curtis D. Collins | Zendy; Shikha Polega | Zendy; Anurag N. Malani | Zendy

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Therapeutic drug monitoring and use of an adjusted body weight strategy for high-dose voriconazole therapy

Author(s) -

Patrick Richards,

Kimberlyn M. Dang,

Carol A. Kauffman,

Kay Lyn Stalker,

David Sudekum,

Lisa Kerr,

Michelle Brinker-Bodley,

Beena Cheriyan,

Nina West,

Curtis D. Collins,

Shikha Polega,

Anurag N. Malani

Publication year - 2016

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkw550

Subject(s) - voriconazole , medicine , dosing , regimen , maintenance dose , therapeutic drug monitoring , pharmacokinetics , trough concentration , loading dose , therapeutic index , gastroenterology , pharmacology , drug , antifungal , dermatology

A high-dose 12 mg/kg/day (6 mg/kg twice daily) voriconazole regimen was recommended by the CDC to treat patients injected with contaminated methylprednisolone acetate that caused a multi-state fungal outbreak in 2012-13. Therapeutic drug monitoring results of this unique regimen are unknown, as is the most appropriate dosing weight for obese patients. We evaluated voriconazole trough measurements for this dosing scheme, as well as the use of adjusted body weight dosing for obese patients.

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