Genome-wide association study of nevirapine hypersensitivity in a sub-Saharan African HIV-infected population | Zendy

Daniel F. Carr | Zendy; Stéphane Bourgeois | Zendy; Mas Chaponda | Zendy; Louise Y.C. Takeshita | Zendy; Andrew P. Morris | Zendy; Elena M. Cornejo Castro | Zendy; Ana Alfirevic | Zendy; Andrew R. Jones | Zendy; Daniel J. Rigden | Zendy; Sam Haldenby | Zendy; Saye Khoo | Zendy; David G. Lalloo | Zendy; Robert S. Heyderman | Zendy; Collet Dandara | Zendy; Elizabeth Kampira | Zendy; Joep J. van Oosterhout | Zendy; Francis Ssali | Zendy; Paula Munderi | Zendy; Giuseppe Novelli | Zendy; Paola Borgiani | Zendy; Matthew R. Nelson | Zendy; Arthur L. Holden | Zendy; Panos Deloukas | Zendy; Munir Pirmohamed | Zendy

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Genome-wide association study of nevirapine hypersensitivity in a sub-Saharan African HIV-infected population

Author(s) -

Daniel F. Carr,

Stéphane Bourgeois,

Mas Chaponda,

Louise Y.C. Takeshita,

Andrew P. Morris,

Elena M. Cornejo Castro,

Ana Alfirevic,

Andrew R. Jones,

Daniel J. Rigden,

Sam Haldenby,

Saye Khoo,

David G. Lalloo,

Robert S. Heyderman,

Collet Dandara,

Elizabeth Kampira,

Joep J. van Oosterhout,

Francis Ssali,

Paula Munderi,

Giuseppe Novelli,

Paola Borgiani,

Matthew R. Nelson,

Arthur L. Holden,

Panos Deloukas,

Munir Pirmohamed

Publication year - 2016

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkw545

Subject(s) - nevirapine , genome wide association study , toxic epidermal necrolysis , medicine , human leukocyte antigen , single nucleotide polymorphism , population , immunology , biology , genetics , human immunodeficiency virus (hiv) , genotype , dermatology , gene , viral load , antigen , environmental health , antiretroviral therapy

The antiretroviral nevirapine is associated with hypersensitivity reactions in 6%-10% of patients, including hepatotoxicity, maculopapular exanthema, Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN).

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