Purification of Zika virus RNA-dependent RNA polymerase and its use to identify small-molecule Zika inhibitors | Zendy

Hongtao Xu | Zendy; Said Hassounah | Zendy; Susan P. Colby-Germinario | Zendy; Maureen Oliveira | Zendy; Clare Fogarty | Zendy; Yudong Quan | Zendy; Ying-Shan Han | Zendy; Olga Golubkov | Zendy; Ilinca Ibanescu | Zendy; Bluma Brenner | Zendy; Brent R. Stranix | Zendy; Mark A. Wainberg | Zendy

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Purification of Zika virus RNA-dependent RNA polymerase and its use to identify small-molecule Zika inhibitors

Author(s) -

Hongtao Xu,

Said Hassounah,

Susan P. Colby-Germinario,

Maureen Oliveira,

Clare Fogarty,

Yudong Quan,

Ying-Shan Han,

Olga Golubkov,

Ilinca Ibanescu,

Bluma Brenner,

Brent R. Stranix,

Mark A. Wainberg

Publication year - 2016

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkw514

Subject(s) - zika virus , polymerase , virology , rna , rna polymerase , rna dependent rna polymerase , biology , virus , genetics , dna , gene

The viral RNA-dependent RNA polymerase (RdRp) enzymes of the Flaviviridae family are essential for viral replication and are logically important targets for development of antiviral therapeutic agents. Zika virus (ZIKV) is a rapidly re-emerging human pathogen for which no vaccine or antiviral agent is currently available.

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