Unravelling the dynamics of selection of multiresistant variants to integrase inhibitors in an HIV-1-infected child using ultra-deep sequencing | Zendy

Karl Stéfic | Zendy; Maud Salmona | Zendy; Marisa Capitao | Zendy; Marion Splittgerber | Zendy; Z. Maakaroun-Vermesse | Zendy; MarieLaure Nere | Zendy; Louis Bernard | Zendy; MarieLaure Chaix | Zendy; Francis Barin | Zendy; Constance Delaugerre | Zendy

Open Access

Unravelling the dynamics of selection of multiresistant variants to integrase inhibitors in an HIV-1-infected child using ultra-deep sequencing

Author(s) -

Karl Stéfic,

Maud Salmona,

Marisa Capitao,

Marion Splittgerber,

Z. Maakaroun-Vermesse,

MarieLaure Nere,

Louis Bernard,

MarieLaure Chaix,

Francis Barin,

Constance Delaugerre

Publication year - 2016

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkw507

Subject(s) - raltegravir , dolutegravir , elvitegravir , sanger sequencing , integrase , genetics , biology , integrase inhibitor , mutant , gene , mutation , virology , antiretroviral therapy , virus , viral load

Ultra-deep sequencing (UDS) allows detection of minority resistant variants (MRVs) with a threshold of 1% and could be useful to identify variants harbouring single or multiple drug-resistance mutations (DRMs).

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