5-Hydroxyethyl-3-tetradecanoyltetramic acid represents a novel treatment for intravascular catheter infections due toStaphylococcus aureus | Zendy

Marta Zapotoczna | Zendy; Ewan J. Murray | Zendy; Siobhan Hogan | Zendy; James P. O’Gara | Zendy; Siri Ram Chhabra | Zendy; Weng C. Chan | Zendy; E. O’Neill | Zendy; Paul Williams | Zendy

Open Access

5-Hydroxyethyl-3-tetradecanoyltetramic acid represents a novel treatment for intravascular catheter infections due toStaphylococcus aureus

Author(s) -

Marta Zapotoczna,

Ewan J. Murray,

Siobhan Hogan,

James P. O’Gara,

Siri Ram Chhabra,

Weng C. Chan,

E. O’Neill,

Paul Williams

Publication year - 2016

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkw482

Subject(s) - staphylococcus aureus , cytotoxicity , microbiology and biotechnology , in vivo , biofilm , chemistry , pseudomonas aeruginosa , in vitro , membrane permeability , bacteria , biology , biochemistry , membrane , genetics

Biofilm infections of intravascular catheters caused by Staphylococcus aureus may be treated with catheter lock solutions (CLSs). Here we investigated the antibacterial activity, cytotoxicity and CLS potential of 5-hydroxyethyl-3-tetradecanoyltetramic acid (5HE-C14-TMA) compared with the related compounds 3-tetradecanoyltetronic (C14-TOA) and 3-tetradecanoylthiotetronic (C14-TTA), which are variants of quorum sensing signalling molecules produced by Pseudomonas aeruginosa .

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