Peptide-conjugated phosphorodiamidate morpholino oligomer (PPMO) restores carbapenem susceptibility to NDM-1-positive pathogensin vitroandin vivo | Zendy

Erin K. Sully | Zendy; Bruce L. Geller | Zendy; Lixin Li | Zendy; Christina M. Moody | Zendy; Stacey M. Bailey | Zendy; Amy L. Moore | Zendy; Michael Wong | Zendy; Patrice Nordmann | Zendy; Seth M. Daly | Zendy; Carolyn R. Sturge | Zendy; David E. Greenberg | Zendy

Open Access

Peptide-conjugated phosphorodiamidate morpholino oligomer (PPMO) restores carbapenem susceptibility to NDM-1-positive pathogensin vitroandin vivo

Author(s) -

Erin K. Sully,

Bruce L. Geller,

Lixin Li,

Christina M. Moody,

Stacey M. Bailey,

Amy L. Moore,

Michael Wong,

Patrice Nordmann,

Seth M. Daly,

Carolyn R. Sturge,

David E. Greenberg

Publication year - 2016

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkw476

Subject(s) - morpholino , in vivo , in vitro , oligomer , conjugated system , microbiology and biotechnology , peptide , chemistry , carbapenem , biology , virology , antibiotics , biochemistry , gene , genetics , zebrafish , organic chemistry , polymer

The objective of this study was to test the efficacy of an inhibitor of the New Delhi metallo-β- lactamase (NDM-1). Inhibiting expression of this type of antibiotic-resistance gene has the potential to restore antibiotic susceptibility in all bacteria carrying the gene.

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