Open AccessImpact of efavirenz pharmacokinetics and pharmacogenomics on neuropsychological performance in older HIV-infected patients
Author(s) -
Uriel Sandkovsky,
Anthony T. Podany,
Courtney V. Fletcher,
Andrew Owen,
Angela Felton-Coleman,
Lee C. Winchester,
Kevin Robertson,
Susan Swindells
Publication year - 2016
Publication title -
journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dkw403
Subject(s) - efavirenz , pharmacokinetics , cyp2b6 , medicine , gastroenterology , pharmacology , human immunodeficiency virus (hiv) , immunology , antiretroviral therapy , viral load , cytochrome p450 , metabolism , cyp3a4
Pharmacokinetics (PK) and pharmacodynamics of efavirenz and its 8-hydroxy metabolite (8-OH-efavirenz) have not been robustly evaluated in older HIV-infected persons.
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