Emergence of meningococci with reduced susceptibility to third-generation cephalosporins
Author(s) -
AlaEddine Deghmane,
Eva Hong,
MuhamedKheir Taha
Publication year - 2016
Publication title -
journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dkw400
Subject(s) - neisseria meningitidis , microbiology and biotechnology , cephalosporin , multilocus sequence typing , penicillin , meningococcal disease , antibiotics , biology , neisseriaceae , neisseria gonorrhoeae , virology , genotype , gene , bacteria , genetics
Reduced susceptibility to penicillin G in Neisseria meningitidis is mainly due to alterations in PBP2 encoded by the penA gene. However, this phenotype was not associated with reduced susceptibility to third-generation cephalosporins (C3Gs). We aimed to study the emergence of meningococci with reduced susceptibility to C3Gs (MIC >0.06 mg/L) in France since 2012.
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