Antimicrobial activity of antisense peptide–peptide nucleic acid conjugates against non-typeableHaemophilus influenzaein planktonic and biofilm forms
Author(s) -
Taketo Otsuka,
Aimee L. Brauer,
Charmaine Kirkham,
Erin K. Sully,
Melinda M. Pettigrew,
Yong Kong,
Bruce L. Geller,
Timothy F. Murphy
Publication year - 2016
Publication title -
journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dkw384
Subject(s) - haemophilus influenzae , biofilm , peptide , microbiology and biotechnology , antimicrobial , nucleic acid , peptide nucleic acid , conjugate , chemistry , bacteria , biology , virology , antibiotics , biochemistry , genetics , mathematical analysis , mathematics
Antisense peptide nucleic acids (PNAs) are synthetic polymers that mimic DNA/RNA and inhibit bacterial gene expression in a sequence-specific manner.
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