Population pharmacokinetics of micafungin in ICU patients with sepsis and mechanical ventilation | Zendy

Vincent Jullien | Zendy; Élie Azoulay | Zendy; Carole Schwebel | Zendy; Thomas Le Saux | Zendy; PierreEmmanuel Charles | Zendy; Muriel Cornet | Zendy; Bertrand Souweine | Zendy; Kadda Klouche | Zendy; Samir Jaber | Zendy; JeanLouis Trouillet | Zendy; Fabrice Bruneel | Zendy; Martin Cour | Zendy; Joël Cousson | Zendy; Ferhat Meziani | Zendy; Didier Gruson | Zendy; Adeline Paris | Zendy; Michaël Darmon | Zendy; Maïté Garrouste-Orgeas | Zendy; Jean-Christophe Navellou | Zendy; Arnaud Foucrier | Zendy; Bernard Allaouchiche | Zendy; Vincent Das | Zendy; JeanPierre Gangneux | Zendy; Stéphane Ruckly | Zendy; Michel Wolff | Zendy; Jean-François Timsit | Zendy

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Population pharmacokinetics of micafungin in ICU patients with sepsis and mechanical ventilation

Author(s) -

Vincent Jullien,

Élie Azoulay,

Carole Schwebel,

Thomas Le Saux,

PierreEmmanuel Charles,

Muriel Cornet,

Bertrand Souweine,

Kadda Klouche,

Samir Jaber,

JeanLouis Trouillet,

Fabrice Bruneel,

Martin Cour,

Joël Cousson,

Ferhat Meziani,

Didier Gruson,

Adeline Paris,

Michaël Darmon,

Maïté Garrouste-Orgeas,

Jean-Christophe Navellou,

Arnaud Foucrier,

Bernard Allaouchiche,

Vincent Das,

JeanPierre Gangneux,

Stéphane Ruckly,

Michel Wolff,

Jean-François Timsit

Publication year - 2016

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkw352

Subject(s) - micafungin , candida parapsilosis , pharmacokinetics , nonmem , candida glabrata , candida albicans , medicine , population , pharmacodynamics , mechanical ventilation , pharmacology , voriconazole , gastroenterology , biology , microbiology and biotechnology , antifungal , environmental health

To identify the factors associated with the interindividual pharmacokinetic (PK) variability of micafungin and to evaluate the probability of reaching the previously determined PK/pharmacodynamic efficacy thresholds (AUC/MIC >5000 for non-parapsilosis Candida sp. and ≥285 for Candida parapsilosis) with the recommended 100 mg daily dose in ICU patients with sepsis and mechanical ventilation.

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