Voriconazole metabolism is influenced by severe inflammation: a prospective study | Zendy

Anette Veringa | Zendy; Mendy ter Avest | Zendy; Lambert F. R. Span | Zendy; Edwin R. van den Heuvel | Zendy; Daan J. Touw | Zendy; Jan G. Zijlstra | Zendy; Jos G.W. Kosterink | Zendy; Tjip S. van der Werf | Zendy; JanWillem C. Alffenaar | Zendy

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Voriconazole metabolism is influenced by severe inflammation: a prospective study

Author(s) -

Anette Veringa,

Mendy ter Avest,

Lambert F. R. Span,

Edwin R. van den Heuvel,

Daan J. Touw,

Jan G. Zijlstra,

Jos G.W. Kosterink,

Tjip S. van der Werf,

JanWillem C. Alffenaar

Publication year - 2016

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkw349

Subject(s) - voriconazole , medicine , pharmacology , trough concentration , inflammation , gastroenterology , pharmacokinetics , antifungal , dermatology

During an infection or inflammation, several drug-metabolizing enzymes in the liver are down-regulated, including cytochrome P450 iso-enzymes. Since voriconazole is extensively metabolized by cytochrome P450 iso-enzymes, the metabolism of voriconazole can be influenced during inflammation via reduced clearance of the drug, resulting in higher voriconazole trough concentrations.

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