In vivo Mycobacterium tuberculosisfluoroquinolone resistance emergence: a complex phenomenon poorly detected by current diagnostic tests | Zendy

Christine Bernard | Zendy; Alexandra Aubry | Zendy; Aurélie Chauffour | Zendy; Florence Brossier | Zendy; J. Robert | Zendy; Nicolas Véziris | Zendy

Open Access

In vivo Mycobacterium tuberculosisfluoroquinolone resistance emergence: a complex phenomenon poorly detected by current diagnostic tests

Author(s) -

Christine Bernard,

Alexandra Aubry,

Aurélie Chauffour,

Florence Brossier,

J. Robert,

Nicolas Véziris

Publication year - 2016

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkw344

Subject(s) - moxifloxacin , ofloxacin , mycobacterium tuberculosis , genotype , microbiology and biotechnology , context (archaeology) , sanger sequencing , population , biology , drug resistance , tuberculosis , antibiotics , medicine , genetics , mutation , ciprofloxacin , gene , pathology , paleontology , environmental health

Heteroresistance, described both in terms of various point mutations resulting in different levels of resistance and in terms of a mixture of mutant and WT bacilli, is identified in up to one-third of fluoroquinolone (FQ)-resistant Mycobacterium tuberculosis isolates. Heteroresistance is a challenge for current phenotypic and genotypic susceptibility testing (DST) regimes. We aimed to compare the performances of different phenotypic and genotypic DST in the context of FQ heteroresistance by mimicking, in a murine model, the course of selection of FQ resistance during treatment.

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