In vitroactivity of SecA inhibitors in combination with carbapenems against carbapenem-hydrolysing class D β-lactamase-producingAcinetobacter baumannii | Zendy

Chun-Hsiang Chiu | Zendy; Yuhan Liu | Zendy; Yung-Chih Wang | Zendy; YiTzu Lee | Zendy; ShuChen Kuo | Zendy; Te-Li Chen | Zendy; JungChung Lin | Zendy; FuDer Wang | Zendy

Open Access

In vitroactivity of SecA inhibitors in combination with carbapenems against carbapenem-hydrolysing class D β-lactamase-producingAcinetobacter baumannii

Author(s) -

Chun-Hsiang Chiu,

Yuhan Liu,

Yung-Chih Wang,

YiTzu Lee,

ShuChen Kuo,

Te-Li Chen,

JungChung Lin,

FuDer Wang

Publication year - 2016

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkw331

Subject(s) - acinetobacter baumannii , carbapenem , microbiology and biotechnology , acinetobacter , in vitro , imipenem , neisseriaceae , antibiotics , beta lactamase , biology , chemistry , medicine , bacteria , pseudomonas aeruginosa , escherichia coli , antibiotic resistance , biochemistry , gene , genetics

According to our previous study, OXA-58 translocates to the periplasm via the Sec pathway in carbapenem-resistant Acinetobacter baumannii (CRAb). In the present study, carbapenem-hydrolysing class D β-lactamases (CHDLs) belonging to the OXA-23, OXA-40 and OXA-51 families were examined to determine whether they are also Sec-dependent. Additionally, the effects of SecA inhibitors combined with carbapenems against CHDL-producing CRAb were examined.

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