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According to our previous study, OXA-58 translocates to the periplasm via the Sec pathway in carbapenem-resistant Acinetobacter baumannii (CRAb). In the present study, carbapenem-hydrolysing class D β-lactamases (CHDLs) belonging to the OXA-23, OXA-40 and OXA-51 families were examined to determine whether they are also Sec-dependent. Additionally, the effects of SecA inhibitors combined with carbapenems against CHDL-producing CRAb were examined.

the journal of antimicrobial chemotherapy/journal of antimicrobial chemotherapy

<i>In vitro</i>activity of SecA inhibitors in combination with carbapenems against carbapenem-hydrolysing class D β-lactamase-producing<i>Acinetobacter baumannii</i>

In vitroactivity of SecA inhibitors in combination with carbapenems against carbapenem-hydrolysing class D β-lactamase-producingAcinetobacter baumannii