Information provision for antibacterial dosing in the obese patient: a sizeable absence? | Zendy

Sara E. Boyd | Zendy; Esmita Charani | Zendy; Tracy Lyons | Zendy; Gary Frost | Zendy; Alison Holmes | Zendy

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Information provision for antibacterial dosing in the obese patient: a sizeable absence?

Author(s) -

Sara E. Boyd,

Esmita Charani,

Tracy Lyons,

Gary Frost,

Alison Holmes

Publication year - 2016

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkw324

Subject(s) - medicine , dosing , formulary , intensive care medicine , population , antibacterial agent , pharmacology , antibiotics , environmental health , microbiology and biotechnology , biology

Obesity is on course to overtake being underweight as a global disease burden. Obesity alters antibacterial pharmacokinetics (PK) and pharmacodynamics (PD). Historically, drug PK/PD parameters have not been studied in obese populations. This means dose recommendations risk being sub-therapeutic in a population at increased risk of infection. Suboptimal antibacterial prescribing is widely associated with treatment failure, worse clinical outcomes, unnecessary escalation to broad-spectrum therapy and the emergence of antimicrobial resistance (AMR).

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