Pharmacokinetics of high-dose nebulized amikacin in ventilated critically ill patients | Zendy

Antoine Petitcollin | Zendy; PierreFrançois Dequin | Zendy; François Darrouzain | Zendy; Laurent Vecellio | Zendy; Thierry Boulain | Zendy; Denis Garot | Zendy; Gilles Paintaud | Zendy; David Ternant | Zendy; Stéphan Ehrmann | Zendy

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Pharmacokinetics of high-dose nebulized amikacin in ventilated critically ill patients

Author(s) -

Antoine Petitcollin,

PierreFrançois Dequin,

François Darrouzain,

Laurent Vecellio,

Thierry Boulain,

Denis Garot,

Gilles Paintaud,

David Ternant,

Stéphan Ehrmann

Publication year - 2016

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkw313

Subject(s) - amikacin , pharmacokinetics , medicine , volume of distribution , bioavailability , pharmacology , antibacterial agent , population , anesthesia , antibiotics , chemistry , environmental health , biochemistry

Antibiotic nebulization theoretically allows the delivery of high doses to the lungs together with limited systemic exposure and toxicity. This study aimed to describe amikacin pharmacokinetics, and especially its absorption, in patients treated with high-dose nebulized amikacin.

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