Abacavir has no prothrombotic effect on plateletsin vitro | Zendy

Y Diallo | Zendy; Véronique Ollivier | Zendy; Véronique Joly | Zendy; Dorothée Faille | Zendy; Giovanna Catalano | Zendy; Martine JandrotPerrus | Zendy; Antoine Rauch | Zendy; Patrick Yéni | Zendy; Nadine Ajzenberg | Zendy

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Abacavir has no prothrombotic effect on plateletsin vitro

Author(s) -

Y Diallo,

Véronique Ollivier,

Véronique Joly,

Dorothée Faille,

Giovanna Catalano,

Martine JandrotPerrus,

Antoine Rauch,

Patrick Yéni,

Nadine Ajzenberg

Publication year - 2016

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkw303

Subject(s) - abacavir , platelet , pharmacology , platelet activation , medicine , whole blood , adenosine diphosphate , platelet poor plasma , myocardial infarction , in vitro , thrombin , immunology , chemistry , human immunodeficiency virus (hiv) , viral load , biochemistry , platelet aggregation , antiretroviral therapy

HIV patients exposed to abacavir have an increased risk of myocardial infarction, with contradictory results in the literature. The aim of our study was to determine whether abacavir has a direct effect on platelet activation and aggregation using platelets from healthy donors and from HIV-infected patients under therapy with an undetectable viral load.

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