Improved adipose tissue function with initiation of protease inhibitor-only ART | Zendy

Robert T. Maughan | Zendy; Eoin R. Feeney | Zendy; Émilie Capel | Zendy; Jacqueline Capeau | Zendy; Peré Domingo | Zendy; Marta Giralt | Zendy; Joep M. A. Lange | Zendy; Praphan Phanuphak | Zendy; David A. Cooper | Zendy; Peter Reiss | Zendy; Patrick Mallon | Zendy

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Improved adipose tissue function with initiation of protease inhibitor-only ART

Author(s) -

Robert T. Maughan,

Eoin R. Feeney,

Émilie Capel,

Jacqueline Capeau,

Peré Domingo,

Marta Giralt,

Joep M. A. Lange,

Praphan Phanuphak,

David A. Cooper,

Peter Reiss,

Patrick Mallon

Publication year - 2016

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkw301

Subject(s) - lipodystrophy , insulin resistance , endocrinology , adipose tissue , medicine , adipocyte , ritonavir , lopinavir , glucose homeostasis , glut4 , saquinavir , biology , insulin , viral load , immunology , covid-19 , human immunodeficiency virus (hiv) , disease , antiretroviral therapy , infectious disease (medical specialty)

Use of ART containing HIV PIs has previously been associated with toxicity in subcutaneous adipose tissue (SAT), potentially contributing to the development of lipodystrophy and insulin resistance. However, the effect of PIs on SAT function in ART-naive patients independent of other ART classes is unknown. This study aimed to elucidate the effect of initiating PI-only ART on SAT function in ART-naive subjects.

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