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Hypermutable bacteria are causing a drastic problem via their enhanced ability to become resistant. Our objectives were to compare bacterial killing and resistance emergence between differently shaped tobramycin concentration-time profiles at a given fAUC/MIC, and determine the tobramycin exposure durations that prevent resistance.

the journal of antimicrobial chemotherapy/journal of antimicrobial chemotherapy

Resistance suppression by high-intensity, short-duration aminoglycoside exposure against hypermutable and non-hypermutable<i>Pseudomonas aeruginosa</i>

Resistance suppression by high-intensity, short-duration aminoglycoside exposure against hypermutable and non-hypermutablePseudomonas aeruginosa