Resistance suppression by high-intensity, short-duration aminoglycoside exposure against hypermutable and non-hypermutablePseudomonas aeruginosa | Zendy

Vanessa E. Rees | Zendy; Jürgen B. Bulitta | Zendy; Antonio Oliver | Zendy; Brian T. Tsuji | Zendy; Craig R. Rayner | Zendy; Roger L. Nation | Zendy; Cornelia B. Landersdorfer | Zendy

Open Access

Resistance suppression by high-intensity, short-duration aminoglycoside exposure against hypermutable and non-hypermutablePseudomonas aeruginosa

Author(s) -

Vanessa E. Rees,

Jürgen B. Bulitta,

Antonio Oliver,

Brian T. Tsuji,

Craig R. Rayner,

Roger L. Nation,

Cornelia B. Landersdorfer

Publication year - 2016

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkw297

Subject(s) - tobramycin , pseudomonas aeruginosa , microbiology and biotechnology , aminoglycoside , bacteria , antibiotics , pseudomonadaceae , biology , chemistry , genetics

Hypermutable bacteria are causing a drastic problem via their enhanced ability to become resistant. Our objectives were to compare bacterial killing and resistance emergence between differently shaped tobramycin concentration-time profiles at a given fAUC/MIC, and determine the tobramycin exposure durations that prevent resistance.

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