Polymyxin B in combination with doripenem against heteroresistant Acinetobacter baumannii : pharmacodynamics of new dosing strategies | Zendy

Gauri G. Rao | Zendy; Neang S. Ly | Zendy; Jürgen B. Bulitta | Zendy; Rachel L. Soon | Zendy; Marie D. San Roman | Zendy; Patricia N. Holden | Zendy; Cornelia B. Landersdorfer | Zendy; Roger L. Nation | Zendy; Jian Li | Zendy; Alan Forrest | Zendy; Brian T. Tsuji | Zendy

Open Access

Polymyxin B in combination with doripenem against heteroresistant Acinetobacter baumannii : pharmacodynamics of new dosing strategies

Author(s) -

Gauri G. Rao,

Neang S. Ly,

Jürgen B. Bulitta,

Rachel L. Soon,

Marie D. San Roman,

Patricia N. Holden,

Cornelia B. Landersdorfer,

Roger L. Nation,

Jian Li,

Alan Forrest,

Brian T. Tsuji

Publication year - 2016

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkw293

Subject(s) - acinetobacter baumannii , doripenem , pharmacodynamics , dosing , medicine , polymyxin b , antibiotics , polymyxin , microbiology and biotechnology , pharmacology , meropenem , pharmacokinetics , pseudomonas aeruginosa , biology , bacteria , antibiotic resistance , genetics

Polymyxin B is being increasingly utilized as a last resort against resistant Gram-negative bacteria. We examined the pharmacodynamics of novel dosing strategies for polymyxin B combinations to maximize efficacy and minimize the emergence of resistance and drug exposure against Acinetobacter baumannii.

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