Dose optimization of voriconazole/anidulafungin combination against Aspergillus fumigatus using an in vitro pharmacokinetic/pharmacodynamic model and response surface analysis: clinical implications for azole-resistant aspergillosis | Zendy

Maria Siopi | Zendy; Nikolaos Siafakas | Zendy; Sophia Vourli | Zendy; Johan W. Mouton | Zendy; Loukia Zerva | Zendy; Joseph Meletiadis | Zendy

Open Access

Dose optimization of voriconazole/anidulafungin combination against Aspergillus fumigatus using an in vitro pharmacokinetic/pharmacodynamic model and response surface analysis: clinical implications for azole-resistant aspergillosis

Author(s) -

Maria Siopi,

Nikolaos Siafakas,

Sophia Vourli,

Johan W. Mouton,

Loukia Zerva,

Joseph Meletiadis

Publication year - 2016

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkw276

Subject(s) - anidulafungin , voriconazole , echinocandin , pharmacology , pharmacodynamics , aspergillus fumigatus , pharmacokinetics , azole , medicine , aspergillosis , combination therapy , microbiology and biotechnology , biology , fluconazole , caspofungin , immunology , antifungal

Combination therapy of voriconazole with an echinocandin is often employed in order to increase the efficacy of voriconazole monotherapy.

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