Impact of AAC(6′)-Ib-cr in combination with chromosomal-mediated mechanisms on clinical quinolone resistance inEscherichia coli | Zendy

Jesús Machuca | Zendy; Miriam Ortiz-Padilla | Zendy; Esther Recacha | Zendy; Paula Díaz-De-Alba | Zendy; Fernando Docobo-Pérez | Zendy; José Manuel Rodríguez-Martínez | Zendy; Álvaro Pascual | Zendy

Open Access

Impact of AAC(6′)-Ib-cr in combination with chromosomal-mediated mechanisms on clinical quinolone resistance inEscherichia coli

Author(s) -

Jesús Machuca,

Miriam Ortiz-Padilla,

Esther Recacha,

Paula Díaz-De-Alba,

Fernando Docobo-Pérez,

José Manuel Rodríguez-Martínez,

Álvaro Pascual

Publication year - 2016

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkw258

Subject(s) - escherichia coli , plasmid , microbiology and biotechnology , ciprofloxacin , biology , norfloxacin , broth microdilution , enterobacteriaceae , quinolone , antibacterial agent , gene , dna gyrase , genetics , antibiotics , minimum inhibitory concentration

aac(6')-Ib-cr is the most prevalent plasmid-mediated fluoroquinolone (FQ) resistance mechanism in Enterobacteriaceae. We aimed to analyse the interplay between this plasmid-mediated gene and chromosomal-mediated quinolone resistance mechanisms on both FQ resistance and bacterial fitness in Escherichia coli.

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