Activation of type II NADH dehydrogenase by quinolinequinones mediates antitubercular cell death | Zendy

Adam Heikal | Zendy; Kiel Hards | Zendy; ChenYi Cheung | Zendy; Ayana Menorca | Zendy; Mattie S. M. Timmer | Zendy; Bridget L. Stocker | Zendy; Gregory M. Cook | Zendy

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Activation of type II NADH dehydrogenase by quinolinequinones mediates antitubercular cell death

Author(s) -

Adam Heikal,

Kiel Hards,

ChenYi Cheung,

Ayana Menorca,

Mattie S. M. Timmer,

Bridget L. Stocker,

Gregory M. Cook

Publication year - 2016

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkw244

Subject(s) - antimycobacterial , clofazimine , respiratory chain , nadh dehydrogenase , reactive oxygen species , mycobacterium bovis , dehydrogenase , biology , population , chemistry , biochemistry , mycobacterium tuberculosis , microbiology and biotechnology , pharmacology , enzyme , tuberculosis , immunology , medicine , leprosy , environmental health , pathology , protein subunit , gene

Quinolinequinones (QQ) have been shown to inhibit the growth of mycobacterial species, but their mode(s) of action and molecular target(s) remain unknown. To facilitate further development of QQ as antimycobacterial drugs, we investigated the molecular mechanism and target of QQ in mycobacteria.

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