Open AccessPharmacodynamics and differential activity of nitrofurantoin against ESBL-positive pathogens involved in urinary tract infections
Author(s) -
Fiona Fransen,
Maria J. Melchers,
Joseph Meletiadis,
Johan W. Mouton
Publication year - 2016
Publication title -
journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dkw212
Subject(s) - enterobacter cloacae , nitrofurantoin , microbiology and biotechnology , pharmacodynamics , klebsiella pneumoniae , antimicrobial , escherichia coli , biology , antibiotics , ciprofloxacin , pharmacokinetics , pharmacology , biochemistry , gene
Although nitrofurantoin has been used for >60 years for the treatment of uncomplicated urinary tract infections, its pharmacodynamic properties are not fully explored. Use is increasing because of increasing resistance to other antimicrobials due to ESBLs.
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