High susceptibility of MDR and XDR Gram-negative pathogens to biphenyl-diacetylene-based difluoromethyl-allo-threonyl-hydroxamate LpxC inhibitors | Zendy

Marie Titécat | Zendy; Xiaofei Liang | Zendy; ChulJin Lee | Zendy; Audrey Charlet | Zendy; Didier Hocquet | Zendy; Thierry Lambert | Zendy; JeanMarie Pagès | Zendy; René Courcol | Zendy; Florent Sebbane | Zendy; Eric J. Toone | Zendy; Pei Zhou | Zendy; Nadine Lemaître | Zendy

Open Access

High susceptibility of MDR and XDR Gram-negative pathogens to biphenyl-diacetylene-based difluoromethyl-allo-threonyl-hydroxamate LpxC inhibitors

Author(s) -

Marie Titécat,

Xiaofei Liang,

ChulJin Lee,

Audrey Charlet,

Didier Hocquet,

Thierry Lambert,

JeanMarie Pagès,

René Courcol,

Florent Sebbane,

Eric J. Toone,

Pei Zhou,

Nadine Lemaître

Publication year - 2016

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkw210

Subject(s) - microbiology and biotechnology , acinetobacter baumannii , pseudomonas aeruginosa , antibiotics , amikacin , antimicrobial , ciprofloxacin , biology , klebsiella pneumoniae , chemistry , bacteria , escherichia coli , biochemistry , gene , genetics

Inhibitors of uridine diphosphate-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC, which catalyses the first, irreversible step in lipid A biosynthesis) are a promising new class of antibiotics against Gram-negative bacteria. The objectives of the present study were to: (i) compare the antibiotic activities of three LpxC inhibitors (LPC-058, LPC-011 and LPC-087) and the reference inhibitor CHIR-090 against Gram-negative bacilli (including MDR and XDR isolates); and (ii) investigate the effect of combining these inhibitors with conventional antibiotics.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research