A pharmacokinetic–pharmacodynamic model characterizing the emergence of resistantEscherichia colisubpopulations during ertapenem exposure | Zendy

Wanchana Ungphakorn | Zendy; Thomas Tängdén | Zendy; Linus Sandegren | Zendy; Elisabet I. Nielsen | Zendy

Open Access

A pharmacokinetic–pharmacodynamic model characterizing the emergence of resistantEscherichia colisubpopulations during ertapenem exposure

Author(s) -

Wanchana Ungphakorn,

Thomas Tängdén,

Linus Sandegren,

Elisabet I. Nielsen

Publication year - 2016

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkw205

Subject(s) - ertapenem , escherichia coli , microbiology and biotechnology , pharmacodynamics , biology , strain (injury) , bacteria , pharmacokinetics , antibiotics , antibiotic resistance , meropenem , pharmacology , biochemistry , genetics , anatomy , gene

Resistant subpopulations with reduced expression of outer membrane porins have been observed in ESBL-producing Escherichia coli during exposure to ertapenem. The aim of this work was to develop a pharmacokinetic-pharmacodynamic (PKPD) model to characterize the emergence of resistant E. coli during exposure to ertapenem and to predict bacterial killing following different dosing regimens of ertapenem.

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