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The aim of the study was to determine how ESBL-producing Escherichia coli change the expression of metabolic and biosynthesis genes when adapting to inhibitory concentrations of cefotaxime. Secondly, it was investigated whether significantly regulated pathways constitute putative secondary targets that can be used to combat the resistant bacteria.

the journal of antimicrobial chemotherapy/journal of antimicrobial chemotherapy

Adaptive responses to cefotaxime treatment in ESBL-producing<i>Escherichia coli</i>and the possible use of significantly regulated pathways as novel secondary targets

Adaptive responses to cefotaxime treatment in ESBL-producingEscherichia coliand the possible use of significantly regulated pathways as novel secondary targets