Adaptive responses to cefotaxime treatment in ESBL-producingEscherichia coliand the possible use of significantly regulated pathways as novel secondary targets | Zendy

Thea S. B. Møller | Zendy; Martin Holm Rau | Zendy; Charlotte S. Bonde | Zendy; Morten Otto Alexander Sommer | Zendy; Luca Guardabassi | Zendy; John Elmerdahl Olsen | Zendy

Open Access

Adaptive responses to cefotaxime treatment in ESBL-producingEscherichia coliand the possible use of significantly regulated pathways as novel secondary targets

Author(s) -

Thea S. B. Møller,

Martin Holm Rau,

Charlotte S. Bonde,

Morten Otto Alexander Sommer,

Luca Guardabassi,

John Elmerdahl Olsen

Publication year - 2016

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkw198

Subject(s) - cefotaxime , escherichia coli , biology , gene , microbiology and biotechnology , bacteria , plasmid , peptidoglycan , biochemistry , antibiotics , genetics

The aim of the study was to determine how ESBL-producing Escherichia coli change the expression of metabolic and biosynthesis genes when adapting to inhibitory concentrations of cefotaxime. Secondly, it was investigated whether significantly regulated pathways constitute putative secondary targets that can be used to combat the resistant bacteria.

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