A novel small-molecule compound disrupts influenza A virus PB2 cap-binding and inhibits viral replication | Zendy

Shuofeng Yuan | Zendy; Hin Chu | Zendy; Ke Zhang | Zendy; Jiahui Ye | Zendy; Kailash Singh | Zendy; Richard Y. T. Kao | Zendy; Bkc Chow | Zendy; Jie Zhou | Zendy; BoJian Zheng | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

A novel small-molecule compound disrupts influenza A virus PB2 cap-binding and inhibits viral replication

Author(s) -

Shuofeng Yuan,

Hin Chu,

Ke Zhang,

Jiahui Ye,

Kailash Singh,

Richard Y. T. Kao,

Bkc Chow,

Jie Zhou,

BoJian Zheng

Publication year - 2016

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkw194

Subject(s) - docking (animal) , viral replication , influenza a virus , polymerase , binding site , biology , ligand binding assay , virus , virology , replicon , microbiology and biotechnology , chemistry , biochemistry , enzyme , receptor , plasmid , gene , medicine , nursing

The conserved residues 318-483 in the PB2 subunit of influenza A polymerase is an independently folded cap-binding domain (PB2cap) that exhibits a distinct binding mode from other host cap-binding proteins, which suggests that PB2cap might be an ideal drug target. This study aimed to identify a new class of anti-influenza inhibitors that specifically disrupts the interaction between PB2cap and host cap structures.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research