A novel resistance mutation ineccC5of the ESX-5 secretion system confers ofloxacin resistance inMycobacterium tuberculosis | Zendy

Brandon Eilertson | Zendy; Fernanda Maruri | Zendy; Amondrea Blackman | Zendy; Yan Guo | Zendy; Miguel F. Herrera | Zendy; Yuri van der Heijden | Zendy; Yu Shyr | Zendy; Timothy R. Sterling | Zendy

Open Access

A novel resistance mutation ineccC₅of the ESX-5 secretion system confers ofloxacin resistance inMycobacterium tuberculosis

Author(s) -

Brandon Eilertson,

Fernanda Maruri,

Amondrea Blackman,

Yan Guo,

Miguel F. Herrera,

Yuri van der Heijden,

Yu Shyr,

Timothy R. Sterling

Publication year - 2016

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkw168

Subject(s) - ofloxacin , dna gyrase , mycobacterium tuberculosis , efflux , microbiology and biotechnology , biology , mutation , antibacterial agent , tuberculosis , genetics , gene , antibiotics , escherichia coli , ciprofloxacin , medicine , pathology

Fluoroquinolone resistance in Mycobacterium tuberculosis is often conferred by DNA gyrase mutations. However, a substantial proportion of fluoroquinolone-resistant M. tuberculosis isolates do not have such mutations.

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