Reduction in post-operative acute kidney injury following a change in antibiotic prophylaxis policy for orthopaedic surgery: an observational study | Zendy

Heather Walker | Zendy; Andrea Patton | Zendy; Gwen Bayne | Zendy; Charis Marwick | Zendy; Jacqueline Sneddon | Zendy; Peter Davey | Zendy; Dilip Nathwani | Zendy; Samira Bell | Zendy

Open Access

Reduction in post-operative acute kidney injury following a change in antibiotic prophylaxis policy for orthopaedic surgery: an observational study

Author(s) -

Heather Walker,

Andrea Patton,

Gwen Bayne,

Charis Marwick,

Jacqueline Sneddon,

Peter Davey,

Dilip Nathwani,

Samira Bell

Publication year - 2016

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkw166

Subject(s) - medicine , observational study , antibiotic prophylaxis , acute kidney injury , orthopedic surgery , antibiotics , surgery , reduction (mathematics) , chemistry , biochemistry , geometry , mathematics

Evidence has shown that a prophylactic antibiotic regimen of flucloxacillin and gentamicin for orthopaedic surgery was associated with increased rates of post-operative acute kidney injury (AKI). This resulted in changes in the national antibiotic policy recommendation for orthopaedic surgical prophylaxis. This study aimed to assess whether this change from flucloxacillin and gentamicin to co-amoxiclav was associated with changes in the rates of AKI and Clostridium difficile infection (CDI).

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