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Pathophysiological changes in critically ill patients can cause severely altered pharmacokinetics and widely varying antibiotic exposures. The impact of altered pharmacokinetics on bacterial killing and resistance has not been characterized in the dynamic hollow-fibre in vitro infection model (HFIM).

the journal of antimicrobial chemotherapy/journal of antimicrobial chemotherapy

Effect of different renal function on antibacterial effects of piperacillin against<i>Pseudomonas aeruginosa</i>evaluated via the hollow-fibre infection model and mechanism-based modelling

Effect of different renal function on antibacterial effects of piperacillin againstPseudomonas aeruginosaevaluated via the hollow-fibre infection model and mechanism-based modelling