Effect of different renal function on antibacterial effects of piperacillin againstPseudomonas aeruginosaevaluated via the hollow-fibre infection model and mechanism-based modelling | Zendy

Phillip J. Bergen | Zendy; Jürgen B. Bulitta | Zendy; Carl M. J. Kirkpatrick | Zendy; Kate E. Rogers | Zendy; Megan J. McGregor | Zendy; Steven C. Wallis | Zendy; David L. Paterson | Zendy; Jeffrey Lipman | Zendy; Jason A. Roberts | Zendy; Cornelia B. Landersdorfer | Zendy

Open Access

Effect of different renal function on antibacterial effects of piperacillin againstPseudomonas aeruginosaevaluated via the hollow-fibre infection model and mechanism-based modelling

Author(s) -

Phillip J. Bergen,

Jürgen B. Bulitta,

Carl M. J. Kirkpatrick,

Kate E. Rogers,

Megan J. McGregor,

Steven C. Wallis,

David L. Paterson,

Jeffrey Lipman,

Jason A. Roberts,

Cornelia B. Landersdorfer

Publication year - 2016

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkw153

Subject(s) - piperacillin , pharmacokinetics , pseudomonas aeruginosa , renal function , dosing , antibiotics , pharmacodynamics , medicine , pharmacology , antibacterial agent , microbiology and biotechnology , biology , bacteria , genetics

Pathophysiological changes in critically ill patients can cause severely altered pharmacokinetics and widely varying antibiotic exposures. The impact of altered pharmacokinetics on bacterial killing and resistance has not been characterized in the dynamic hollow-fibre in vitro infection model (HFIM).

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