Subtherapeutic tetracycline concentrations aggravateSalmonellaTyphimurium infection by increasing bacterial virulence | Zendy

Elin Verbrugghe | Zendy; Alexander Van Parys | Zendy; Roel Haesendonck | Zendy; Bregje Leyman | Zendy; Filip Boyen | Zendy; Freddy Haesebrouck | Zendy; Frank Pasmans | Zendy

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Subtherapeutic tetracycline concentrations aggravateSalmonellaTyphimurium infection by increasing bacterial virulence

Author(s) -

Elin Verbrugghe,

Alexander Van Parys,

Roel Haesendonck,

Bregje Leyman,

Filip Boyen,

Freddy Haesebrouck,

Frank Pasmans

Publication year - 2016

Publication title -

journal of antimicrobial chemotherapy

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkw152

Subject(s) - virulence , salmonella , microbiology and biotechnology , tetracycline , biology , antibiotics , salmonella enterica , salmonella infection , antimicrobial , antibiotic resistance , gene , bacteria , genetics

Antibiotics are among the most frequently prescribed drugs in human and animal medicine. With antibiotic resistance being a serious threat to veterinary and public health, the prudent use of antibiotics receives much attention. Less well known is that incorrect use of antimicrobial agents may also lead to increased bacterial virulence with the potential of a more severe clinical course of infection. Therefore, the aim of this study was to investigate the effect of subtherapeutic doses of tetracyclines on htpG virulence gene expression in Salmonella Typhimurium and on the course of salmonellosis.

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