Dysregulation ofmprFanddltABCDexpression among daptomycin-non-susceptible MRSA clinical isolates | Zendy

Arnold S. Bayer | Zendy; Nagendra N. Mishra | Zendy; Ambrose L. Cheung | Zendy; Aileen Rubio | Zendy; SooJin Yang | Zendy

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Dysregulation ofmprFanddltABCDexpression among daptomycin-non-susceptible MRSA clinical isolates

Author(s) -

Arnold S. Bayer,

Nagendra N. Mishra,

Ambrose L. Cheung,

Aileen Rubio,

SooJin Yang

Publication year - 2016

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkw142

Subject(s) - biology , daptomycin , regulon , transcription (linguistics) , gene , genetics , transcription factor , regulation of gene expression , gene expression , phenotype , staphylococcus aureus , microbiology and biotechnology , bacteria , vancomycin , linguistics , philosophy

In small series or individual reports, SNPs within the mprF ORF and dysregulation of its expression in Staphylococcus aureus have been linked to daptomycin resistance (DAP-R) via a proposed gain-in-function mechanism. Similarly, dysregulation of dltABCD has also been associated with DAP-R.

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