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In small series or individual reports, SNPs within the mprF ORF and dysregulation of its expression in Staphylococcus aureus have been linked to daptomycin resistance (DAP-R) via a proposed gain-in-function mechanism. Similarly, dysregulation of dltABCD has also been associated with DAP-R.

Dysregulation ofmprFanddltABCDexpression among daptomycin-non-susceptible MRSA clinical isolates