Effect ofblaregulators on the susceptible phenotype and phenotypic conversion for oxacillin-susceptiblemecA-positive staphylococcal isolates | Zendy

Pilong Liu | Zendy; Huping Xue | Zendy; Zhaowei Wu | Zendy; Junfei Ma | Zendy; Xin Zhao | Zendy

Open Access

Effect ofblaregulators on the susceptible phenotype and phenotypic conversion for oxacillin-susceptiblemecA-positive staphylococcal isolates

Author(s) -

Pilong Liu,

Huping Xue,

Zhaowei Wu,

Junfei Ma,

Xin Zhao

Publication year - 2016

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkw123

Subject(s) - microbiology and biotechnology , sccmec , phenotype , biology , staphylococcus aureus , agar dilution , staphylococcus , meticillin , gene , antibacterial agent , bacteria , antibiotics , minimum inhibitory concentration , micrococcaceae , methicillin resistant staphylococcus aureus , genetics

The bla regulatory system is critical in the regulation of mecA expression particularly when staphylococci lack the mec regulator. We sought to evaluate the effect of bla regulators on the cryptic methicillin-resistant phenotype and resistance conversion under β-lactam exposure in oxacillin-susceptible or oxacillin-resistant mecA-positive staphylococcal isolates.

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