l-Serine potentiates fluoroquinolone activity againstEscherichia coliby enhancing endogenous reactive oxygen species production | Zendy

Xiangke Duan | Zendy; Xue Huang | Zendy; Xiaoyu Wang | Zendy; Shuangquan Yan | Zendy; Siyao Guo | Zendy; Abualgasim Elgaili Abdalla | Zendy; Changwu Huang | Zendy; Jianping Xie | Zendy

Open Access

l-Serine potentiates fluoroquinolone activity againstEscherichia coliby enhancing endogenous reactive oxygen species production

Author(s) -

Xiangke Duan,

Xue Huang,

Xiaoyu Wang,

Shuangquan Yan,

Siyao Guo,

Abualgasim Elgaili Abdalla,

Changwu Huang,

Jianping Xie

Publication year - 2016

Publication title -

journal of antimicrobial chemotherapy

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkw114

Subject(s) - serine , ofloxacin , escherichia coli , multidrug tolerance , moxifloxacin , microbiology and biotechnology , antibiotics , bacteria , chemistry , biochemistry , biology , pharmacology , enzyme , biofilm , ciprofloxacin , genetics , gene

The increase in multiple antimicrobial-resistant bacteria seriously threatens global public health. Novel effective strategies are urgently needed. l-Serine was reported as the most effective amino acid inhibitor against bacterial growth and can sensitize Escherichia coli cells to gentamicin. It is currently unknown whether l-serine affects other type of antibiotics such as β-lactams and fluoroquinolones.

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