Pharmacodynamics of anti-HIV gene therapy using viral vectors and targeted endonucleases | Zendy

Pavitra Roychoudhury | Zendy; Harshana S. De Silva Feelixge | Zendy; Harlan L. Pietz | Zendy; Daniel Stone | Zendy; Keith R. Jerome | Zendy; Joshua T. Schiffer | Zendy

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Pharmacodynamics of anti-HIV gene therapy using viral vectors and targeted endonucleases

Author(s) -

Pavitra Roychoudhury,

Harshana S. De Silva Feelixge,

Harlan L. Pietz,

Daniel Stone,

Keith R. Jerome,

Joshua T. Schiffer

Publication year - 2016

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkw104

Subject(s) - transduction (biophysics) , reporter gene , transgene , biology , computational biology , genetic enhancement , gene , viral vector , vectors in gene therapy , vector (molecular biology) , gene delivery , gene expression , expression cassette , genetics , recombinant dna , biochemistry

A promising curative approach for HIV is to use designer endonucleases that bind and cleave specific target sequences within latent genomes, resulting in mutations that render the virus replication incompetent. We developed a mathematical model to describe the expression and activity of endonucleases delivered to HIV-infected cells using engineered viral vectors in order to guide dose selection and predict therapeutic outcomes.

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