Tert-butyl benzoquinone: mechanism of biofilm eradication and potential for use as a topical antibiofilm agent | Zendy

Nicola Ooi | Zendy; E.A. Eady | Zendy; Jonathan H. Cove | Zendy; Alex J. O’Neill | Zendy

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Tert-butyl benzoquinone: mechanism of biofilm eradication and potential for use as a topical antibiofilm agent

Author(s) -

Nicola Ooi,

E.A. Eady,

Jonathan H. Cove,

Alex J. O’Neill

Publication year - 2016

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkw100

Subject(s) - biofilm , microbiology and biotechnology , antimicrobial , staphylococcus aureus , bacteria , chemistry , gentamicin , biology , antibiotics , genetics

Tert-butyl benzoquinone (TBBQ) is the oxidation product of tert-butyl hydroquinone (TBHQ), an antimicrobial food additive with >40 years of safe use. TBBQ displays potent activity against Staphylococcus aureus biofilms in vitro. Here, we report on studies to further explore the action of TBBQ on staphylococcal biofilms, and provide a preliminary preclinical assessment of its potential for use as a topical treatment for staphylococcal infections involving a biofilm component.

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