Comparative effects of overproducing the AraC-type transcriptional regulators MarA, SoxS, RarA and RamA on antimicrobial drug susceptibility inKlebsiella pneumoniae | Zendy

Juan-Carlos Jiménez-Castellanos | Zendy; Wan Nur Ismah Wan Ahmad Kamil | Zendy; Ching Hei Phoebe Cheung | Zendy; Maryann S. Tobin | Zendy; James Brown | Zendy; Sophie G. Isaac | Zendy; Kate J. Heesom | Zendy; Thamarai Schneiders | Zendy; Matthew B. Avison | Zendy

Open Access

Comparative effects of overproducing the AraC-type transcriptional regulators MarA, SoxS, RarA and RamA on antimicrobial drug susceptibility inKlebsiella pneumoniae

Author(s) -

Juan-Carlos Jiménez-Castellanos,

Wan Nur Ismah Wan Ahmad Kamil,

Ching Hei Phoebe Cheung,

Maryann S. Tobin,

James Brown,

Sophie G. Isaac,

Kate J. Heesom,

Thamarai Schneiders,

Matthew B. Avison

Publication year - 2016

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkw088

Subject(s) - overproduction , porin , efflux , microbiology and biotechnology , klebsiella pneumoniae , biology , antibiotics , bacterial outer membrane , biochemistry , escherichia coli , gene

In Klebsiella pneumoniae, overproduction of RamA and RarA leads to increased MICs of various antibiotics; MarA and SoxS are predicted to perform a similar function. We have compared the relative effects of overproducing these four AraC-type regulators on envelope permeability (a combination of outer membrane permeability and efflux), efflux pump and porin production, and antibiotic susceptibility in K. pneumoniae.

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