A pharmacokinetic–pharmacodynamic (PKPD) model based onin vitrotime–kill data predicts thein vivoPK/PD index of colistin | Zendy

David D. Khan | Zendy; Lena E. Friberg | Zendy; Elisabet I. Nielsen | Zendy

Open Access

A pharmacokinetic–pharmacodynamic (PKPD) model based onin vitrotime–kill data predicts thein vivoPK/PD index of colistin

Author(s) -

David D. Khan,

Lena E. Friberg,

Elisabet I. Nielsen

Publication year - 2016

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkw057

Subject(s) - colistin , in vivo , pharmacodynamics , in silico , pseudomonas aeruginosa , pharmacology , pharmacokinetics , in vitro , antibiotics , medicine , biology , microbiology and biotechnology , bacteria , biochemistry , genetics , gene

For antibiotics, extensive animal PKPD studies are often performed to evaluate the PK/PD driver for subsequent use when recommending dosing regimens. The aim of this work was to evaluate a PKPD model, developed based on in vitro time-kill data for colistin, in predicting the relationships between PK/PD indices and the bacterial killing previously observed in mice.

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