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For antibiotics, extensive animal PKPD studies are often performed to evaluate the PK/PD driver for subsequent use when recommending dosing regimens. The aim of this work was to evaluate a PKPD model, developed based on in vitro time-kill data for colistin, in predicting the relationships between PK/PD indices and the bacterial killing previously observed in mice.

A pharmacokinetic–pharmacodynamic (PKPD) model based onin vitrotime–kill data predicts thein vivoPK/PD index of colistin