Are first-generation cephalosporins obsolete? A retrospective, non-inferiority, cohort study comparing empirical therapy with cefazolin versus ceftriaxone for acute pyelonephritis in hospitalized patients | Zendy

Athena L V Hobbs | Zendy; Katherine M. Shea | Zendy; Mitchell J. Daley | Zendy; R. Gordon Huth | Zendy; Theresa Jaso | Zendy; Jack Bissett | Zendy; Vagish Hemmige | Zendy

Open Access

Are first-generation cephalosporins obsolete? A retrospective, non-inferiority, cohort study comparing empirical therapy with cefazolin versus ceftriaxone for acute pyelonephritis in hospitalized patients

Author(s) -

Athena L V Hobbs,

Katherine M. Shea,

Mitchell J. Daley,

R. Gordon Huth,

Theresa Jaso,

Jack Bissett,

Vagish Hemmige

Publication year - 2016

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkw035

Subject(s) - ceftriaxone , cefazolin , medicine , cephalosporin , retrospective cohort study , intensive care medicine , antibiotics , microbiology and biotechnology , biology

Literature is lacking regarding the utilization of first-generation cephalosporins for the treatment of acute pyelonephritis. The aim of this study was to determine whether cefazolin is non-inferior to ceftriaxone for the empirical treatment of acute pyelonephritis in hospitalized patients. The primary outcome included a composite of symptomatic resolution plus either defervescence at 72 h or normalization of serum white blood cell count at 72 h (non-inferiority margin 15%). Secondary outcomes included length of stay and 30 day readmission. A subgroup analysis of the composite outcome was also conducted for imaging-confirmed pyelonephritis.

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