Drug permeation and barrier damage inLeishmania-infected mouse skin | Zendy

Katrien Van Bocxlaer | Zendy; Vanessa Yardley | Zendy; Sudaxshina Murdan | Zendy; Simon L. Croft | Zendy

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Drug permeation and barrier damage inLeishmania-infected mouse skin

Author(s) -

Katrien Van Bocxlaer,

Vanessa Yardley,

Sudaxshina Murdan,

Simon L. Croft

Publication year - 2016

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkw012

Subject(s) - cutaneous leishmaniasis , barrier function , leishmania major , transepidermal water loss , human skin , medicine , drug , drug delivery , leishmania , pathology , pharmacology , chemistry , leishmaniasis , stratum corneum , biology , parasite hosting , genetics , organic chemistry , world wide web , computer science , microbiology and biotechnology

Pathological disorder can disrupt the barrier integrity of the skin, thereby altering the drug delivery from topical formulations to the target site. Cutaneous leishmaniasis (CL) is an infection of the dermal layers of the skin and manifests as a variety of skin lesions from defined nodular forms to plaques and chronic ulcers. The aim of this work was to characterize the physiology and barrier integrity of the Leishmania-infected BALB/c mouse skin and how they impacted delivery of drugs into the skin.

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