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Clostridium difficile infection (CDI) is a primary cause of antibiotic-associated diarrhoeal illness. Current therapies are insufficient as relapse rates following antibiotic treatment range from 25% for initial treatment to 60% for treatment of recurrence. In this study, we looked at the efficacy of SQ641 in a murine model of CDI. SQ641 is an analogue of capuramycin, a naturally occurring nucleoside-based compound produced by Streptomyces griseus.

the journal of antimicrobial chemotherapy/journal of antimicrobial chemotherapy

Treatment of<i>Clostridium difficile</i>infection using SQ641, a capuramycin analogue, increases post-treatment survival and improves clinical measures of disease in a murine model

Treatment ofClostridium difficileinfection using SQ641, a capuramycin analogue, increases post-treatment survival and improves clinical measures of disease in a murine model