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KPC-2-producing Klebsiella pneumoniae (KPC-KP) ST258 has been rapidly expanding and is often associated with serious nosocomial infections. Last-line antibiotics such as colistin and tigecycline often remain the only treatment option. We describe here the evolving genetic background of KPC-KP isolates in Crete, Greece.

Emergence of pan-resistance in KPC-2 carbapenemase-producingKlebsiella pneumoniaein Crete, Greece: a close call