Phylogeny, resistome and mobile genetic elements of emergent OXA-48 and OXA-245Klebsiella pneumoniaeclones circulating in Spain | Zendy

Marı́a Pérez-Vázquez | Zendy; Jesús Oteo | Zendy; Silvia García-Cobos | Zendy; Belén Aracil | Zendy; Simon R. Harris | Zendy; Adriana Ortega | Zendy; D. Fontanals | Zendy; Juan Manuel Hernández | Zendy; Sonia Solís | Zendy; José Campos | Zendy; Gordon Dougan | Zendy; Robert A. Kingsley | Zendy

Open Access

Phylogeny, resistome and mobile genetic elements of emergent OXA-48 and OXA-245Klebsiella pneumoniaeclones circulating in Spain

Author(s) -

Marı́a Pérez-Vázquez,

Jesús Oteo,

Silvia García-Cobos,

Belén Aracil,

Simon R. Harris,

Adriana Ortega,

D. Fontanals,

Juan Manuel Hernández,

Sonia Solís,

José Campos,

Gordon Dougan,

Robert A. Kingsley

Publication year - 2016

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkv458

Subject(s) - klebsiella pneumoniae , resistome , mobile genetic elements , biology , microbiology and biotechnology , phylogenetics , klebsiella infections , klebsiella , genetics , virology , gene , escherichia coli , genome

The global emergence of OXA-48-producing Klebsiella pneumoniae clones is a significant threat to public health. We used WGS and phylogenetic analysis of Spanish isolates to investigate the population structure of blaOXA-48-like-expressing K. pneumoniae ST11 and ST405 and to determine the distribution of resistance genes and plasmids encoding blaOXA-48-like carbapenemases.

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