Open AccessPharmacokinetics andin vivoefficacy of optimized oncocin derivatives
Author(s) -
Rico Schmidt,
Eszter Ostorházi,
Elisabeth Wende,
Daniel Knappe,
Ralf Hoffmann
Publication year - 2016
Publication title -
journal of antimicrobial chemotherapy
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dkv454
Subject(s) - pharmacokinetics , in vivo , pharmacology , medicine , chemistry , biology , genetics
To evaluate the efficacy of antimicrobial peptide Onc112 in a lethal Escherichia coli infection model and the pharmacokinetics of Onc72 and Onc112 administered intravenously or intraperitoneally in mice.
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