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Pharmacodynamics of vancomycin for CoNS infection: experimental basis for optimal use of vancomycin in neonates
Author(s) -
V. Ramos-Martín,
Adam Johnson,
Joanne Livermore,
Laura McEntee,
Joanne Goodwin,
Sarah Whalley,
Fernando Docobo-Pérez,
Tim Felton,
Wei Zhao,
Evelyne JacqzAigrain,
Mike Sharland,
M. Turner,
William Hope
Publication year - 2016
Publication title -
journal of antimicrobial chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.124
H-Index - 194
eISSN - 1460-2091
pISSN - 0305-7453
DOI - 10.1093/jac/dkv451
Subject(s) - pharmacodynamics , pharmacokinetics , cmax , medicine , vancomycin , pharmacology , population , cons , minimum inhibitory concentration , antibiotics , biology , microbiology and biotechnology , staphylococcus aureus , bacteria , computer science , genetics , programming language , environmental health
CoNS are the most common cause of neonatal late-onset sepsis. Information on the vancomycin pharmacokinetics/pharmacodynamics against CoNS is limited. The aim of this study was to characterize vancomycin pharmacokinetic/pharmacodynamic relationships for CoNS and investigate neonatal optimal dosage regimens.

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