Identification and characterization of haemofungin, a novel antifungal compound that inhibits the final step of haem biosynthesis | Zendy

Dafna Ben Yaakov | Zendy; Anna Rivkin | Zendy; Gabriel Mircus | Zendy; Nathaniel D. Albert | Zendy; Anna-Maria Dietl | Zendy; Dimitry Kovalerchick | Zendy; Shmuel Carmeli | Zendy; Hubertus Haas | Zendy; Dimitrios P. Kontoyiannis | Zendy; Nir Osherov | Zendy

Open Access

Identification and characterization of haemofungin, a novel antifungal compound that inhibits the final step of haem biosynthesis

Author(s) -

Dafna Ben Yaakov,

Anna Rivkin,

Gabriel Mircus,

Nathaniel D. Albert,

Anna-Maria Dietl,

Dimitry Kovalerchick,

Shmuel Carmeli,

Hubertus Haas,

Dimitrios P. Kontoyiannis,

Nir Osherov

Publication year - 2016

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkv446

Subject(s) - aspergillus fumigatus , biology , microbiology and biotechnology , aspergillus nidulans , galleria mellonella , in vivo , biochemistry , virulence , mutant , gene

During recent decades, the number of invasive fungal infections among immunosuppressed patients has increased significantly, whereas the number of effective systemic antifungal drugs remains low and unsatisfactory. The aim of this study was to characterize a novel antifungal compound, CW-8/haemofungin, which we previously identified in a screen for compounds affecting fungal cell wall integrity.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research