Simulation of the impact of rifampicin on once-daily darunavir/ritonavir pharmacokinetics and dose adjustment strategies: a population pharmacokinetic approach | Zendy

Laura Dickinson | Zendy; Alan Winston | Zendy; Marta Boffito | Zendy; Saye Khoo | Zendy; David Back | Zendy; Marco Siccardi | Zendy

Open Access

Simulation of the impact of rifampicin on once-daily darunavir/ritonavir pharmacokinetics and dose adjustment strategies: a population pharmacokinetic approach

Author(s) -

Laura Dickinson,

Alan Winston,

Marta Boffito,

Saye Khoo,

David Back,

Marco Siccardi

Publication year - 2015

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkv439

Subject(s) - darunavir , ritonavir , rifampicin , pharmacology , pharmacokinetics , medicine , population , drug interaction , bioavailability , human immunodeficiency virus (hiv) , virology , viral load , tuberculosis , environmental health , pathology , antiretroviral therapy

Treatment of HIV/TB coinfection is challenging due to potent drug-drug interactions between antiretrovirals and rifampicin. The effect of rifampicin on darunavir/ritonavir has not been studied. Population pharmacokinetic modelling was applied to investigate the interaction and generate alternative doses to inform clinical trial design.

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