The purine analogues abacavir and didanosine increase acetaminophen-induced hepatotoxicity by enhancing mitochondrial dysfunction | Zendy

Ana BlasGarcía | Zendy; Alberto Martí-Rodrigo | Zendy; Víctor M. Víctor | Zendy; Miriam Polo | Zendy; Fernando Alegre | Zendy; Haryes A. Funes | Zendy; Nadezda Apostolova | Zendy; Juan V. Esplugues | Zendy

Open Access

The purine analogues abacavir and didanosine increase acetaminophen-induced hepatotoxicity by enhancing mitochondrial dysfunction

Author(s) -

Ana BlasGarcía,

Alberto Martí-Rodrigo,

Víctor M. Víctor,

Miriam Polo,

Fernando Alegre,

Haryes A. Funes,

Nadezda Apostolova,

Juan V. Esplugues

Publication year - 2016

Publication title -

journal of antimicrobial chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.124

H-Index - 194

eISSN - 1460-2091

pISSN - 0305-7453

DOI - 10.1093/jac/dkv424

Subject(s) - didanosine , abacavir , mitochondrial toxicity , pharmacology , context (archaeology) , mitochondrion , acetaminophen , medicine , toxicity , purine , chemistry , biology , immunology , human immunodeficiency virus (hiv) , biochemistry , antiretroviral therapy , enzyme , viral load , paleontology

NRTIs are essential components of HIV therapy with well-documented, long-term mitochondrial toxicity in hepatic cells, but whose acute effects on mitochondria are unclear. As acetaminophen-induced hepatotoxicity also involves mitochondrial interference, we hypothesized that it would be exacerbated in the context of ART.

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