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Tigecycline represents one of the last-line therapeutics to combat multidrug-resistant bacterial pathogens, including VRE and MRSA. The German National Reference Centre for Staphylococci and Enterococci has received 73 tigecycline-resistant Enterococcus faecium and Enterococcus faecalis isolates in recent years. The precise mechanism of how enterococci become resistant to tigecycline remains undetermined. This study documents an analysis of the role of efflux pumps in tigecycline resistance in clinical isolates of Enterococcus spp.

the journal of antimicrobial chemotherapy/journal of antimicrobial chemotherapy

Tigecycline resistance in clinical isolates ofEnterococcus faeciumis mediated by an upregulation of plasmid-encoded tetracycline determinantstet(L) andtet(M)